Haematotoxicity from chemotherapy course 1 already observed?
No
Yes
Leukopenia:
WHO=4 (<
1
)
(WBC*10³/mm³)
WHO=3 (>=
1
and <
2)
WHO=2 (>=
2
and <
3)
WHO=1 (>=
3
and <
4)
WHO=0 (>=
4
)
missing
Thrombopenia:
WHO=4 (<
25
)
(Platelets*10³/mm³)
WHO=3 (>=
25
and <
50)
WHO=2 (>=
50
and <
75)
WHO=1 (>=
75
and <
100)
WHO=0 (>=
100
)
missing
Anaemia:
WHO=4 (<
6.5
)
(Haemoglobin*g/dl)
WHO=3 (>=
6.5
and <
8)
WHO=2 (>=
8
and <
9.5)
WHO=1 (>=
9.5
and <
11)
WHO=0 (>=
11
)
missing
Chemotherapy regimen
6 cycles
CHOP
and 14-day intervals with
G-CSF
6 cycles
CHOEP
and 14-day intervals with
G-CSF
6 cycles
CHOP
and 21-day intervals without
G-CSF
6 cycles
CHOEP
and 21-day intervals without
G-CSF
Factor
Age
18–60 years
61–75 years
Gender
male
female
unknown
Overweight (body size
cm)
*
no
yes
unknown
Initial γGT
γGT≤Upper Normal Limit
γGT>Upper Normal Limit
unknown
Ann Arbor stage
I, II
III, IV
unknown
Bone marrow involvement
no
yes and ≤25%
unknown
Initial LDH
LDH≤Upper Normal Limit
LDH>Upper Normal Limit
unknown
Initial leucocyte count
>7100×10³/mm³
≤7100×10³/mm³
unknown
Initial thrombocyte count
>150×10³/mm³
≤150×10³/mm³
unknown
Initial haemoglobin
female: >12; male: >13 g/dl
female: ≤12; male: ≤13 g/dl
unknown
Performance status ECOG
0, 1
2, 3
unknown
Vincristine (body surface area
m²)
#
≤1.05 mg/m²
>1.05 mg/m²
unknown
*
The limit is calculated as 115% Brocca-index (body size in cm − 100)
#
With the body surface area information it is possible to decide whether the dose limit is exceeded (2 mg / body surface area > 1.05 mg/m²) or not
Show models
Leukopenia
Thrombopenia
Anaemia
Show expected toxicity for
Cycle 1-3
Cycle 4-6
both
Colour scheme
Multicoloured
Blue
Last modified 11/12/07 10:57 am